A Low Amine Low MSG Diet

Managing Dietary Amines and MSG, October 2002

Contents

Introduction

This article presents guidelines for avoiding dietary amines and free glutamates. In fact you may want to consult these web sites before continuing with this article.

I deal with both topics simultaneously, because there is considerable overlap. Foods that are fermented, aged, processed, or overcooked, often contain both amines and glutamates. In fact, you may have trouble determining which chemical you are reacting to. But you should make the effort, because there are important differences. Glutamate responders can eat tuna fish, and amine responders can eat jello. And so on.

As you will see below, it isn't just a matter of avoiding certain foods or food additives, although that is part of the protocol. A long list of rules governs the storage and cooking of meats and grains. You'd think you were reading the Talmud! Indeed, this protocol becomes part of your religion, because the slightest mistake might lead to violent insanity or a savage migraine.

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Buying And Storing Meat

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Buying And Storing Fish

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Cooking Meat/Fish

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Yeast

Some amine responders react to yeast/mold, even in trace amounts. This may include the B vitamins routinely added to breads and cereals here in the States. Yeast is involved in the production of these vitamins. As of this writing, Austrailia does not add B vitamins to its rice, so nobody from RPAH is watching for this type of reaction.

Another problem with fortified grains is the conveyance. Some companies use corn starch to spread the vitamins through the wheat or rice, and corn starch often contains MSG.

You may not have candida, but yeasts and molds could still be a concern. We must borrow several ideas from the candida diet. All food must be fresh, not just the meats. When a can of pairs is opened, it should be eaten that day.

Apples and melons are not good choices for the salicylate challenge, because they harbor natural yeast. Try zucchini and onions and waterchestnuts first.

If you tolerate yeast, and most of us do, you must still avoid yeast extract, yeast nutrients, and autolyzed yeast. These are very high in amines and MSG.

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Fruits

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Vegetables

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Oils

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Grains and Baking

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Dairy

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Eggs

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Miscellaneous

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Water

Tap water contains chloramine, NCl3, which is often (mistakenly) referred to as simply "chlorine". An occasional glass of tap water is ok, but you should drink distilled water most of the time. Boiled tap water, e.g. for cooking, is fine, since chloramine is a volatile compound. I have read reports that claim the opposite, that chloramine remains in boiled or long standing water, but if it weren't volatile, then why would baths or showers be a problem? (See below.) I guess you'll have to experiment for yourself.

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Hygiene

Showers and baths can be a problem due to the chloramines described above. If you already have amines in your system, the chloramine vapors from the hot water can trigger a headache or asthma attack. My son's asthma flared up, simply from drawing a hot bath - even before he stepped in. The risk is mitigated if the curtain and bathroom door are left open. Privacy must yield when a person's health is at stake.

Fast showers are generally safer than baths. Less water is used (hence less chloramine is released), the falling water keeps the air moving, and you can learn to get in and out quickly. You may want to turn off the water while washing hair etc.

Some can't handle a shower at all, and have switched to shallow sponge baths.

Regular Coldgate toothpaste seems to be ok. Many other brands are also acceptable, but some contain amines, so be careful. Lightly scented soaps and shampoos shouldn't cause too much trouble, unless you are already loaded down with amines.

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Meds

Any drug that is an amine should be considered unsafe. This includes all decongestants and cough suppressants. Contac 12-hour, for instance, contains two amines, and will send an amine responder up the wall. Before taking any drug, check the last five letters of the chemical name of the active ingredient, e.g. dextroamphetamine. If it ends in amine, you're probably, but not always, in trouble. Dextromethorafan is also unsafe, even though it doesn't end in amine. Similarly for psuedoephedrine.

As you can see, the chemical name is only an approximate indicator. Some amines are locked up, internal to the molecule, and other non-amines produce amine metabolites in the body. As a more reliable indicator, any drug that interacts with MAO inhibiters is unsafe. After all, the A in MAO stands for amine. Check drug interactions in your drug guide, or ask your pharmacist.

Tylenol and Benadryl are ok for mild aches and allergies respectively. Be sure these meds are plain, not supplemented with other cold medicines, and not coated with dyes or flavors. Note that Benadryl is intended to treat allergy symptoms, but some say it helps with the runny nose of a cold. Others say it doesn't. It does make you sleepy however, and if that's what you're aiming for (at night), then maybe it helps after all.

Use nasal sprays to relieve congestion. Try a pure saline solution first. If this doesn't help, ask for Spray-Tish, or any spray with active ingredient Tramazoline Hydrochloride. Be sure the nose is clear of liquid before applying the medicine, or it won't help.

Applying the same purity disclaimer, antibiotics and non-steroidal anti-inflamatories are ok. Codeine, found in Tylenol III, seems to be an acceptable pain killer, though there are questions regarding its use with children. Codeine can also act as a cough suppressant, and this is important, as all true cough suppressants are verboten. For persistent coughs try nebulized Atrovent. Atrovent is a synthetic atropine and is an asthma medication. It often works very well for coughs of all kinds, even coughs not related to asthma - no one knows why.

Do not treat asthma or croup with steam! Hot showers, and even humidifiers, send chloramines into the air, and make the symptoms worse. (A humidifier is ok if you use distilled water.) When our child has asthma we place her in a sitting position in a chair or bed and turn on the tv or radio, giving her something else to think about, so she doesn't panic. We wrap her in a blanket; warmth seems to help. sometimes a heating pad can be applied directly to the chest. If necessary, use inhalers, as prescribed by your physician, though I have yet to see a dramatic improvement from these asthma medications. Benadryl can be a life saver - it literally kept our daughter out of the hospital during a severe asthma attack.

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The Histamine Connection

If you think there is random noise in your data, noise that makes it nearly impossible to figure out which foods are safe and which foods are not, you're probably right. Your child may be reacting to something in the air, something you can't track at all. The following is taken from various pages under www.claritin.com.


When a person is exposed to an allergen, a complex chain of events begins in the body's immune system. Several conditions must occur before allergy symptoms such as a runny nose or sneezing arise. Playing a main role in the development of these conditions is a substance called `histamine.'

What is histamine?

Histamine is a naturally occurring chemical found in several types of cells throughout the body. After it is released, it helps to control many body functions by attaching to receptors located on blood vessels, membranes, and glands. Histamine is also stored in `specialized cells' called mast cells and basophils. During an allergic reaction, these allergy cells release histamine. The histamine then attaches itself to blood vessels, causing leakage of fluid, which in turn leads to nasal congestion. The histamine also attaches to mucus-secreting glands, causing increased production of mucus. When histamine attaches near nerve endings, it can cause itching and sneezing. Ultimately, the release of histamine leads to `acute' allergy symptoms such as itching, swelling, redness, watery eyes, and a runny nose. Histamine can also allow the release of other chemicals that further fuel the allergic reaction, worsening allergy symptoms hours after exposure to the allergen.

How do antihistamines work to relieve allergy symptoms?

`Antihistamines' are medications that block histamine from attaching to cells, thereby reducing the itching, swelling, redness, and change in mucus production that histamine may cause.

Once a day CLARITINŽ does not cause drowsiness when taken at the recommended doses, which is common with all over-the-counter and some prescription antihistamines.


Checking with webbook.nist.gov/chemistry/, histamine has a formula of C5H9N3. (I can't convey the structural formula here.) It's a very interesting molecule - no oxygen, and hydrogen poor. A nasty little amine to be sure.

If you don't suffer from amines, all this may not be very interesting, but if you do, this is extremely relevant. It means your body can manufacture its own amines in response to allergens. This is separate and apart from any amines you might ingest. And a few milligrams of histamine might be enough to affect behavior, even though it does not produce any overt allergy symptoms such as a runny nose. With no reason to think otherwise, you might decide that a challenge failed, simply because the pollen count was high that day. conversely, you might be tearing your hair out in frustration, because you know you served entirely safe foods, yet your child is having a reaction. If you are in North America, you might want to sign up for the daily pollen report from www.claritin.com. That way you can track some (certainly not all) of the environmental allergens, and correlate this data with your symptoms.

We administer Benadryl liquid, dyphenhydramine hydrochloride, when our kids are showing allergy symptoms. That seems to keep the histamines at bay. Benadryl improves our kids' nasal congestion and behavior simultaneously. It's not a miracle cure, but it helps. Does it block amines, or just make them sleepy? Who knows.

Here's what a migraine sufferer has to say about antihistamines.


I am a migraine sufferer and have been since I was 6 years old. I recently changed Doctors, and she gave me an Antihistamin called Vomex[A], a Suppository with working ingredient 150 mg Dimenhydrinat. I never get warnings with my migraines. They just show up and within 10 minutes I am vomitting and crying from pain. I stuff a Vomex[A] up and lay down for an hour then take paracetamol and most of the time my migraine goes away within an hour. Funny how an antihistamin helps me so much but then again I am ultra-sensitive to amines. A small piece of chocolate will put me in bed. The Vomex[A] works within 10 minutes for me and also calms me down so that I can get rid of the headache. Only use the suppositories as the tablettes have junk in them.

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Candida And Other Unwelcome Microbes

When my son first went failsafe he got worse, much worse. And I'm not talking about withdrawl symptoms; it went on for weeks! violent insanity, and a horrible alcohol smell on his breath and skin, like stale beer. So my experience with failsafe was not positive, and I went off in other directions. Good thing I did.

My kids have no trouble with amines or glutamates, and never did. Thus I cannot vouch for anything on this web page, personally. Others swear by it, and follow these guidelines to the letter. I continue to host this page for their benefit, but I rarely look at it any more.

The only section that held true for us was the bath. John definitely reacted to the chloramine that escaped into the air. Everything else on this page is compiled from other people's experiences.

So - what on Earth was wrong with my son, and why did it flare up on the failsafe diet, which avoids everything artificial, and promotes whole grains, vegetables, and gently cooked meats? For a while we thought it was candida. Close, but no cigar. The culprit is a bacteria, which remains unidentified, and unconquered. Either way, sugar and starch feed the microbial parasite, and the colony thrives. These nasty organisms ferment food and dump their mysterious byproducts into the blood stream. Some of these foreign compounds cross the blood brain barrier and produce insanity. Others leak out through his pores and produce that unusual smell, which I have never smelled anywhere else before.

The failsafe diet is very high in carbs. My son was reacting to every meal, because the microbes were churning out toxins in response to everything he ate. I kept looking for patterns, and there were none. We tried low carb diets, as recommended by the candida books, but that didn't work either. That's because a bacteria is a different animal. You need a brand new diet, which has yet to be documented in the literature. As far as I know, we are breaking new ground.

You can read about our four-year investigation here.

You can try all the diets in the world, and write everything down, and look for patterns using modern statistical methods, but if you have any unwelcome guests in your digestive tract, you're going to react to everything, in different ways and under different circumstances, because the food is fermenting inside you. If you can't find any patterns, look for a biological connection.

We use to think ulcers were a malady of diet. We now know that diet plays only a minor role; most ulcers are bacterial infections. Other illnesses are being traced to bacteria and/or viruses even as I write. So it is with John's ADHD.

Oh well - back to the topic at hand.

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Testing For Amines Invitro

One of the amine responders on the Failsafe discussion list employs a commercial test kit to help her establish the amine content of various foods. It's not perfect, but it's better than testing everything invivo. :-) Her explanation follows.


I use an Ammonia Test kit, intended for aquaria. Not all ammonia test kits are of use for testing for the presence of amines in foods, but some are. To test for amines the kit must be one that detects both free and bound ammonia (total ammonia). Detecting bound ammonia causes "false positives" when testing aquarium water, and so is not the best for that, but is wonderfully useful for testing foods for amines.

My test kit (Aquarium Pharmaceuticals) uses a Modified Nessler Reagent (that's what it says on the label) and therefore tests for both bound and free ammonia. Amines have ammonia molecules bound up as part of their structure; the reagent breaks the amine bond, freeing the ammonia and making it available to react as ammonia in the water added to the food sample. This gives me a rough idea as to the presence or absence of amines in the food. However, I suspect that the amount of fat in the food and the solubility / suspendability of the food also affects the result.

Despite this limitation the results I have obtained using it do seem to tie in very nicely with reactions from the various super amine responders (including me) in the group.

If you're not sure which kit to buy, I recommend the AquariumPharm test kit. The AP test kit is very simple to use. I add a small piece of the food, preferably ground or mashed up, to about 2.5 ml of distilled water and then shake well in the test tube so that the food is mixed as well as possible with the water. The water must be distilled water as tap water will usually contain cloramine or other impurities which may result in a false positive on the food. The neutral pH of the distilled water is also important as an acid pH may result in the reagent not working. I then add 4 drops of the reagent and shake well and wait about 5 minutes for the results to develop. Many foods show a result even as you are adding the reagent.

Because the reaction depends on colour - that is the sample turns yellow, orange or brown if ammonia (from amines in the food) is present - some foods cannot be tested easily. For instance I haven't tried to test beetroot. When I have tested foods that are dark in colour such as carob (which contains some amines BTW) I have set up two test tubes with the sample of the food and water and added reagent to only one so that I can compare the sample I've tested to the control sample. This can be the only way to be sure that a change in colour has in fact occurred.

If you think you're doing something wrong, because everything you test seems to have at least some amines, you're probably doing everything right. The amine-free foods can be counted on one hand: white sugar, white rice, and very fresh chicken - that's about it. Assuming you want more variety than that, eat the foods that elicit only a modest color change, several minutes after the reagent is added.


I have tried this test kit, but I've found it difficult to use, and the results inconclusive. As stated above, almost everything reacts, to some degree, so it's hard to tell. Oh well - there's the information.

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Amines And The Brain

I ran across an interesting article in the 07/21/2001 issue of Science News. The authors link some of our favorite amines, e.g. tyramine, to serious mental illness. Of course there is no mention of reducing dietary amines to ameliorate the problem.

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Hats

Remember, it's not always the food. Amines and migraines go hand in hand, yet some migraines can be caused by external forces. Several people report that any physical pressure on the head can produce a migraine. They avoid hats, helmets, headbands, even barrettes. I guess that puts a damper on motorcycle riding (helmets required by law) - not that you could handle the exhaust fumes in any case.

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MCS

Speaking of exhaust fumes, be on the lookout for strange smells or other airborn chemicals. Perfumes, solvents, tars, industrial chemicals, new cars, new furniture, new carpetting - they can all evoke symptoms. The outgassing is worse on hot days. If possible, leave new carpetting, curtains, furniture, etc, outdoors for a few days, to "vent". Stick with pure cloth upholstery, rather than synthetics. This is the world of multiple chemical sensitivity, MCS, and I'm afraid it is beyond the scope of this article. My kids don't have MCS, and I'm eternally grateful.

Actually that's not quite true. My daughter always developed an asthma attack after she smelled strong perfume. I could set my clock by it - and I'm talking about a pretty serious attack. We tried to keep her away from artificial fragrances, but then exercise in cold weather brought it on. So we kept her indoors on cold days, but then she started having smaller asthma attacks for no apparent reason. The list of triggers was getting longer and longer. Fortunately this form of MCS disappeared completely when we changed her diet. Her reaction to airborn chemicals was secondary; her reaction to excess carbohydrates was primary. She can now walk down the perfume aisle in the store and sniff all the samples with no ill effects.

That's just one anecdote, but others have also reported a drop in MCS when they cut back on amines and/or salicylates. Of course some people will always be sensitive to these chemicals, no matter what they eat.

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Contact The Author

Please send any additions or corrections to Karl Dahlke, at eklhad@comcast.net.

Click here to visit my web site, which contains more articles on foods and symptomology.

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